سنة النشر

2021

العنوان

Synthesis and Biological Activity of New Sulfonamide Derivatives

الخلاصة

The widespread of resistance to antibacterial agents that became threatening made it essential to search for new antibacterial agents with new mechanisms of action. Different amino acids, dipeptides, and polypeptides derivatives were synthesized and tried as antibacterial agents, some of which were found to possess antibacterial activity. Five derivatives were prepared, the Ethyl-Para amino benzoate, ethyl 4-(phenylsulfonamido) benzoate, N-(4-(hydrazinecarbonyl) phenyl) benzene and N-(4-(2-(4-(dimethylamino) benbenzylidene) hydrazine carbonyl) phephenyl) benzene. The methods used for the identification of synthesized derivatives include elemental analysis, thin layer chromatography, infrared spectroscopy and melting point determination. The Preliminary study of antimicrobial activity for the target compounds showed that the compounds (4 and 5) had no activity against Staphylococcus aureus, while showed moderate activity against Escherichia coli, when compare to Ciprofloxacin. These compounds are thus promising targets for further researches in the antibacterial wide field. © 2021, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.